Due to the importance of innovation, in recent years, several activities have been carried out to identify the factors affecting the creation of innovation. In this regard, since one of the important indicators of creating innovation is the number of patents registered, so the present study seeks to identify the most important factors affecting patents in the country. To achieve this goal, all patents registered during the years 1390 to 1395 were identified and analyzed by referring to the official Gazette of the country. Also, by reviewing the research literature and interviewing experts, the most important factors influencing the inventions were identified and five quantitative factors whose data were available for all provinces of the country were selected to continue the analysis. Then, using a regression analysis test, the effect of the factors on the number of patents registered in the provinces of the country was investigated. The results show that the per capita factor of the number of Knowledge-based Firms in each province has the greatest impact on the number of patents. Also, the factors of workshops with research and development licenses and the number of master and Ph.D. students have a great impact on the number of patents after the above factor and the factor of the distance between the province capital to Tehran has an inverse and moderate effect on the number Has patents registered in each province.